PRP And Minoxidil - A Powerful Combo: 5 Studies To Know

PRP and minoxidil combination – 5 studies you need to know

Prp Minoxidil Blog Post

PRP and minoxidil - is one better than the other? Is a combination best? and What about nanoxidil?

The battle against female and male pattern baldness has seen significant advancements with the introduction of Platelet Rich Plasma (PRP) therapy and its combination with traditional at-home treatments like minoxidil. 

PRP therapy, a process that involves extracting a patient’s blood, centrifuging it to isolate growth factor-rich plasma, and then injecting this into the scalp, aims to stimulate hair follicle regeneration at the site of hair loss. 

Enhancing this professional treatment, the use of minoxidil or its newer counterpart, nanoxidil, at home seeks to further stimulate the hair follicles, promoting growth in the active phase of the hair cycle. 

Nanoxidil emerges as a promising alternative, boasting a similar molecular structure to minoxidil but with modifications intended to minimize side effects and potentially increase effectiveness. By aiming for better scalp absorption and reduced irritation, nanoxidil represents an evolution in hair loss treatment strategies, offering hope for those seeking alternatives to minoxidil.

Nanoxidil Minoxidil

Study on Nanoxidil for female pattern hair loss

In a study focused on Female Pattern Hair Loss (FPHL), researchers evaluated the efficacy and tolerability of Spectral DNC-N (Vincenzi et al., 2019).

Spectral.DNC-N® is produced by DS Laboratories and is formulated with a 5% concentration of Nanoxidil, which is a complex blend that includes a potassium channel opener, pyrrolidinyl diaminopyrimidine oxide, azelaic acid, lysophosphatidic acid, and copper tripeptide-1. This composition is further enriched with various established hair growth enhancers and components known for their anti-inflammatory effects.

The results were promising, showing a statistically significant reduction in hair shedding by the third month, alongside an increase in hair mass index – indicating not just reduced loss but also gains in hair density. These improvements were not only maintained but enhanced by the sixth month, with the hair shedding score further dropping to 1.6 and the hair mass sustained.

Furthermore, 75% of the participants experienced an increase in overall hair density. The study concluded that Spectral.DNC-N® is effective in significantly reducing hair shedding and increasing hair mass and density in women with early stages of FPHL. 

These benefits became apparent after just three months of treatment and were further improved with extended treatment up to six months. The product was well-tolerated by patients, who reported high levels of satisfaction with the treatment outcome.


Here are five studies that looked at the effectiveness of PRP and minoxidil combination or PRP versus minoxidil for hair health:

1. 2023 study on the effectiveness of PRP therapy versus minoxidil treatment in patients with AGA

Shah et al. (2023) conducted a randomized controlled trial to evaluate the effectiveness of PRP therapy versus minoxidil treatment in patients with Androgenetic Alopecia (AGA). Participants were assigned to receive either PRP or minoxidil. 

Following a 12-week treatment period, the hair pull test was administered, and the number of hairs extracted was recorded. 

The results revealed that 91.7% of the participants in the PRP group had a negative hair pull test, which was significantly higher than the 69.4% reported in the minoxidil group.

 This indicates that PRP therapy may be more effective than minoxidil in treating AGA, particularly within the study’s patient population

The results suggest the potential for enhancing patient adherence and satisfaction by providing a more favorable alternative for those who are not satisfied with the outcomes or side effects of topical minoxidil treatment.


2. A randomized double-blinded placebo control trial that explored the effectiveness of standalone PRP, PRP combined with minoxidil, compared to placebo and standard treatments

Prp Minoxidil Hair Density

In this study, researchers explored the effectiveness of PRP therapy, both on its own and in combination with topical minoxidil, compared to placebo and standard treatments  (Singh et al., 2020).  The study assessed the impact of these interventions on hair density.

Conducted as a randomized, double-blinded placebo control trial, the research divided participants into four groups: 

First group: Received topical minoxidil only.

Second group: Received PRP and minoxidil.

Third group: Given normal saline as a placebo.

Fourth group: treated with PRP alone. 

The results indicated the most significant improvement in the second group treated with PRP and minoxidil. The PRP and minoxidil group experienced the highest increase in hair density, followed by PRP alone (the fourth group), and minoxidil alone (the first group), while the placebo group experienced a decrease in hair density (the third group). 

3. 2022 study found combination therapy with platelet-rich plasma and minoxidil leads to superior results for hair health

Prp Minoxidil Combined

In this study, researchers explored the effectiveness of PRP  therapy, both independently and in combination with minoxidil (Elena & Irina, 2022). The study was divided into three groups for observation.

 First group: received a dual treatment combining PRP and minoxidil (5%). 

Second group: was treated exclusively with PRP injections. 

Third group: used the 5% minoxidil alone.

The results were significant. The PRP and minoxidil combination group experienced a remarkable improvement, with a 32% increase in hair density, a 26% increase in hair shaft diameter, a 30% decrease in vellus hair (finer, shorter hair), and a 39% reduction in telogen hair (the resting phase of the hair cycle). These improvements substantially surpassed the results observed in the groups treated solely with PRP or minoxidil.


The study’s conclusions suggest that PRP and minoxidil, when used in tandem, enhance each other’s efficacy in treating AGA. This synergistic effect underscores the potential of their combined application as a highly promising approach for individuals battling androgenetic alopecia, offering new hope for those seeking effective treatment options.


4. 2024 study looking at PRP and minoxidil versus PRP alone in new hair regeneration

In a very recent study, researchers explored the effectiveness of combining PRP therapy with topical minoxidil versus using PRP alone for the treatment of androgenetic alopecia in men (Ruthvik et al., 2024). The study aimed to determine whether this combined therapy could offer better results in reducing hair loss and promoting the regeneration of new hair.

The results revealed significant improvements in the group treated with both PRP and minoxidil. Specifically, this group showed a greater increase in hair shaft diameter across all postoperative periods, with statistical significance observed at one month, two months and three months after treatment. 

The study concluded that combining PRP therapy with topical minoxidil is a more effective treatment for enhancing both the quality (measured by hair shaft diameter) and quantity (measured by hair follicle density) of hair compared to using PRP alone. 

This combination approach offers a promising solution for men experiencing androgenetic alopecia, suggesting that it can significantly improve hair regrowth and reduce hair loss.


5. Study exploring the efficacy of PRP against topical minoxidil 5% for alopecia areata

In a study aimed at exploring treatments for Alopecia Areata (AA), a common form of nonscarring hair loss, researchers compared the efficacy of PRP therapy against topical minoxidil 5% (El Taieb et al., 2017). The study involved divided participants into three groups. 

First group: Received only topical minoxidil 5%.

Second group:  treated with PRP only.

Third group: received placebo only. 

The findings indicated that both the minoxidil and PRP treatment groups experienced significant hair growth compared to the placebo group, validating the effectiveness of these treatments in managing AA

Notably, the PRP group showed an earlier response in terms of hair regrowth, a reduction in short vellus hair, and dystrophic hair, in contrast to the minoxidil and placebo groups. 

The study conclusively suggests that PRP injections are more effective than topical minoxidil 5% in treating Alopecia Areata, as evidenced by both clinical and trichoscopic examinations. 

This research highlights the potential of PRP as a superior treatment modality for AA, offering hope for individuals seeking effective solutions for this challenging condition.

Understanding Hair Loss Treatments: Dispelling Myths

It’s crucial to have an informed discussion about hair loss treatments to clear up common misconceptions. Here are some key points to consider:


Hair Shedding: It’s normal to experience some hair shedding during the initial stages of treatment as older, telogen phase (resting phase) hairs are replaced by new growth.


Setting Realistic Expectations: Achieving results from follicular stimulation with daily at-home care requires a long-term commitment. Visible improvements typically take 3-4 months to appear and are not the result of a quick fix.


Minoxidil Side Effects: While it’s common for some patients to experience itching and redness with minoxidil use, these symptoms are typically manageable. However, if the discomfort becomes unbearable or if severe allergic reactions occur, it’s important to seek medical advice. 

Nanoxidil may be a safer alternative for those who want to minimize the risk of unwanted side effects.


In the quest to conquer hair loss, the journey of discovery and innovation has led to significant strides in treatment options, merging cutting-edge science with proven therapies. The integration of PRP therapy and minoxidil or nanoxidil showcases a holistic approach to tackling both female and male pattern baldness. 

Through rigorous scientific studies and clinical trials, the efficacy of these treatments has been illuminated, offering renewed hope and tangible results to those afflicted by hair loss.

Moreover, the exploration of treatments like Spectral.DNC-N®, enriched with nanoxidil, opens new avenues for those seeking alternatives with minimized side effects and maximized effectiveness. The positive outcomes from these studies affirm the potential of combined therapies in achieving superior results in hair regeneration and health.

As we navigate through the complexities of hair loss treatment, it is crucial to demystify common misconceptions and set realistic expectations. 

Understanding that treatments like PRP, minoxidil, and nanoxidil are part of a long-term strategy rather than a quick fix is essential for achieving and maintaining results.

In conclusion, the battle against hair loss is advancing, with PRP therapy and minoxidil standing out as key players in a growing arsenal of effective treatments. For individuals grappling with hair loss, these developments offer a beacon of hope and a path towards reclaiming not just their hair, but also their confidence and well-being. 

Embracing these advancements and seeking personalized treatment plans from reputable clinics like LMC – Laser Medical Clinic can pave the way to a future where hair loss is no longer an insurmountable challenge but a condition with viable and effective solutions.


Tackle your hair loss today

At LMC – Laser Medical Clinic, we specialize in bespoke PRP hair treatments that are designed to target and treat the root causes of hair loss. Our cutting-edge PRP therapy, combined with the proven effectiveness of minoxidil or the innovative nanoxidil, offers a comprehensive approach to hair regeneration and health.

But why choose LMC – Laser Medical Clinic for your hair restoration journey? Because we believe in personalized care. Our team of experts will work with you to develop a treatment plan tailored to your specific needs and hair loss pattern, ensuring you receive the most effective treatment possible.

Don’t let hair loss hold you back any longer. Contact LMC – Laser Medical Clinic today to schedule your consultation and discover how our bespoke PRP hair treatments can transform your hair and restore your confidence. Together, we can achieve the results you’ve been dreaming of.



El Taieb, M. A., Ibrahim, H., Nada, E. A., & Seif Al‐Din, M. (2017). Platelets rich plasma versus minoxidil 5% in treatment of alopecia areata: A trichoscopic evaluation. Dermatologic Therapy, 30(1), e12437.

Elena, E. P., & Irina, O. S. (2022). Combination therapy with platelet-rich plasma and minoxidil leads to better clinical results than monotherapy with these methods in men with androgenetic alopecia. International Journal of Trichology, 14(1), 1.

Ruthvik, S., John, R. S., George, M., Kumar, S. P., & Krishnan, M. (2024). Comparison of Efficacy of Platelet-Rich Plasma With and Without Topical Minoxidil for Hair Growth in Patients With Androgenetic Alopecia: A Prospective Study. Cureus, 16(2).

Shah, R., Asim, M., Ouellette, S., Sharif, S., Shah, A., & Rao, B. (2023). A randomized control trial comparing the efficacy of platelet-rich plasma and 5% topical minoxidil for the treatment of androgenetic alopecia. J Drugs Dermatol, 22(9), 905–909.

Singh, S. K., Kumar, V., & Rai, T. (2020). Comparison of efficacy of platelet-rich plasma therapy with or without topical 5% minoxidil in male-type baldness: A randomized, double-blind placebo control trial. Indian Journal of Dermatology, Venereology and Leprology, 86, 150.

Vincenzi, C., Marisaldi, B., Tosti, A., & Patel, B. (2019). Effects of a new topical treatment containing several hair growth promoters in women with early female pattern hair loss. Skin Appendage Disorders, 5(3), 146–151.


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